In silico and in vitro analyses of a novel FoxO1 agonist reducing Aβ levels via downregulation of BACE1

通过下调BACE1降低a β 水平的新型FoxO1激动剂的计算机和体外分析

Through in silico and in vitro, N-(3-methylisothiazol-5-yl)-2-(2-oxobenzo[d] oxazol-3 (2H)-yl) acetamide (compound D), as a novel FoxO1 agonist, can downregulate the levels of Aβ1-40 and Aβ1-42 by inhibiting BACE1. Compound D could be useful in the treatment of AD.

通过计算机模拟和体外实验，N-(3-甲基异噻唑-5-基)-2-(2-氧代苯并 [d] oxazol-3 (2h)-基) 乙酰胺 (化合物D) 作为一种新型的FoxO1激动剂，可以通过抑制bace1来下调Aβ1-40和Aβ1-42的水平。化合物D可用于治疗AD。

REF: Lv MT, Wang HC, Meng XW, et al. In silico and in vitro analyses of a novel FoxO1 agonist reducing Aβ levels via downregulation of BACE1. CNS Neurosci Ther. 2024;30(3):e14140. doi:10.1111/cns.14140 PMID: 36892036 PMCID: PMC10915984

Abnormal characteristic static and dynamic functional network connectivity in idiopathic normal pressure hydrocephalus

特发性正常压力脑积水的异常特征静态和动态功能网络连接

The current study is the first study in iNPH cohort to combine a dynamic analysis framework with classical sFNC to investigate changes in brain connectivity from both static and dynamic perspectives, providing extra information on the underlying mechanisms of iNPH.

当前的研究是iNPH队列中的第一项研究，该研究将动态分析框架与经典sFNC相结合，从静态和动态角度研究大脑连通性的变化，从而提供有关iNPH潜在机制的更多信息。

REF: Huang W, Fang X, Li S, et al. Abnormal characteristic static and dynamic functional network connectivity in idiopathic normal pressure hydrocephalus. CNS Neurosci Ther. 2024;30(3):e14178. doi:10.1111/cns.14178 PMID: 36949617 PMCID: PMC10915979

The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease

3HFWC纳米物质的症状前治疗可降低阿尔茨海默病5XFAD小鼠模型的斑块负荷

A potential of 3HFWC, a hydroxylated fullerenol derivative, to affect amyloid-b aggregation was evaluated in the 5xFAD transgenic mouse model of Alzheimer's disease (AD). The effect of the treatment was confirmed through NIRS analyses and applied machine learning. Our study showed that the presymptomatic, 3-month-long 3HFWC treatment significantly reduced the plaque load in the cortex of treated animals. At the same time, the treatment did not induce astrogliosis, microglial activation, and synaptic vilnerability. These data suggest that 3HFWC can be considered an adjuvant in the development of new therapeutic strategies in AD treatment.

在阿尔茨海默氏病 (AD) 的5xfad转基因小鼠模型中评估了羟基化富勒醇衍生物3HFWC影响淀粉样蛋白b聚集的潜力。通过NIRS分析和应用机器学习证实了治疗的效果。我们的研究表明，症状前3个月的3HFWC治疗显着降低了治疗动物皮质中的斑块负荷。同时，该治疗未诱导星形胶质细胞增生，小胶质细胞激活和突触可vilnerability。这些数据表明，3HFWC可以被认为是AD治疗中新治疗策略开发中的佐剂。

REF: Perovic M, Ciric J, Matovic V, et al. The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease. CNS Neurosci Ther. 2024;30(3):e14188. doi:10.1111/cns.14188 PMID: 36971205 PMCID: PMC10915986

CYP1B1 affects the integrity of the blood–brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity

CYP1B1影响纹状体血脑屏障的完整性和氧化应激: 锰诱导的神经毒性的研究

CYP1B1 deficiency disrupts the integrity of the blood–brain barrier and aggravates manganese-induced neurotoxicity in the striatum. Biotin may play a protective role against manganese-induced neurotoxicity by the up-regulation of CYP1B1.

CYP1B1缺乏会破坏血脑屏障的完整性，并加剧锰诱导的纹状体神经毒性。生物素可能通过上调CYP1B1对锰诱导的神经毒性起保护作用。

REF: Wu J, Li Y, Tian S, et al. CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity. CNS Neurosci Ther. 2024;30(3):e14633. doi:10.1111/cns.14633 PMID: 38429921 PMCID: PMC10907825

Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury

脂肪量和肥胖相关蛋白通过FYN/Drp1轴抑制神经元铁死亡并减轻脑缺血/再灌注损伤

FTO downregulates the m6A level of FYN mRNA, inhibits FYN expression, downregulates FYN protein expression, inhibits phosphorylation of Drp1 protein bound to FYN, inhibits neuronal ferroptosis, and ultimately alleviates MCAO/R cerebral injury.

FTO下调FYN mRNA的m6A水平，抑制FYN表达，下调FYN蛋白表达，抑制与FYN结合的Drp1蛋白磷酸化，抑制神经元铁凋亡，最终减轻MCAO/R脑损伤。

REF: Zhang Y, Gong X. Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury. CNS Neurosci Ther. 2024;30(3):e14636. doi:10.1111/cns.14636 PMID: 38430221 PMCID: PMC10908355

Acetyl-11-keto-beta-boswellic acid modulates macrophage polarization and Schwann cell migration to accelerate spinal cord injury repair in rats

Acetyl-11-keto-beta-boswellic酸调节巨噬细胞极化和雪旺细胞迁移加速大鼠脊髓损伤修复

Acetyl-11-keto-beta-boswellic acid (AKBA) can protect against spinal cord injury by regulating the redox system Nrf2/HO-1 signaling pathway, reducing the ROS generation, and promoting the migration of macrophages to M2 polarization and Schwann cells.

Acetyl-11-keto-beta-boswellic酸 (AKBA) 通过调节氧化还原系统Nrf2/HO-1信号通路，减少ROS的产生，促进巨噬细胞向M2极化和雪旺细胞迁移，从而起到保护脊髓损伤的作用。

REF: Wang Y, Xiong Z, Qiao Y, et al. Acetyl-11-keto-beta-boswellic acid modulates macrophage polarization and Schwann cell migration to accelerate spinal cord injury repair in rats. CNS Neurosci Ther. 2024;30(3):e14642. doi:10.1111/cns.14642 PMID: 38430464 PMCID: PMC10908365

Human umbilical cord mesenchymal stem cells reverse depression in rats induced by chronic unpredictable mild stress combined with lipopolysaccharide

人脐带间充质干细胞逆转慢性温和不可预见性应激联合脂多糖诱导的大鼠抑郁

Rat depression can be reversed or recovered by treatment with hUC-MSCs.

大鼠抑郁症可以通过用huc-mscs治疗来逆转或恢复。

REF: Wang P, Li Y, Song Y, et al. Human umbilical cord mesenchymal stem cells reverse depression in rats induced by chronic unpredictable mild stress combined with lipopolysaccharide. CNS Neurosci Ther. 2024;30(3):e14644. doi:10.1111/cns.14644 PMID: 38433020 PMCID: PMC10909725

Inflammatory marker profiles and in-hospital neurological deterioration in patients with acute minor ischemic stroke

急性轻度缺血性卒中患者的炎症标志物概况和院内神经功能恶化

Elevated hsCRP and IL-6 levels indicated higher ND risk. Adding inflammatory cytokines significantly improved risk classification, with IL-6 as the main contributor.

hsCRP和IL-6水平升高表明ND风险较高。添加炎性细胞因子显著改善了风险分类，IL-6是主要贡献者。

REF: Yi L, Li ZX, Jiang YY, et al. Inflammatory marker profiles and in-hospital neurological deterioration in patients with acute minor ischemic stroke. CNS Neurosci Ther. 2024;30(3):e14648. doi:10.1111/cns.14648 PMID: 38432871 PMCID: PMC10909616

Predictors for early-onset psychotic symptoms in patients newly diagnosed with Parkinson's disease without psychosis at baseline: A 5-year cohort study

初诊无精神病的帕金森病患者早发精神病症状的预测因素: 一项5年队列研究

Greater gastrointestinal autonomic dysfunction, presence of pRBD, and Aβ42: total-tau ratio could independently predict early onset of psychotic symptoms in newly diagnosed PD (diagnosed with PD for 2 years or less at screening visit) with no psychosis at baseline.

更大的胃肠道自主神经功能障碍，pRBD的存在和Aβ42: 总tau比率可以独立预测新诊断的PD (在筛查就诊时诊断为PD 2 °c或更短) 的精神病症状的早期发作，并且在基线时没有精神病。

REF: Chen J, Chen B, Zhao D, et al. Predictors for early-onset psychotic symptoms in patients newly diagnosed with Parkinson's disease without psychosis at baseline: A 5-year cohort study. CNS Neurosci Ther. 2024;30(3):e14651. doi:10.1111/cns.14651 PMID: 38432692 PMCID: PMC10909617