Association of thyroid hormone sensitivity index with stroke in patients with coronary artery disease

冠心病患者甲状腺激素敏感指数与脑卒中的相关性研究

Thyroid hormones (THs) will affect the occurrence and prognosis of stroke, and the research on THs sensitivity index and stroke in patients with coronary heart disease (CHD) is scarce. The goal of this study is to look into the relationship between central and peripheral THs sensitivity index and stroke in patients with CHD. This study demonstrates that the increase in the central THs sensitivity index and the decrease in the peripheral THs sensitivity index are associated with a higher risk of stroke in CHD patients, and provides new ideas for the assessment of stroke in patients with CHD.

甲状腺激素(TH)会影响卒中的发生和预后，而对TH敏感性指数与冠心病(CHD)患者卒中关系的研究较少。本研究的目的是探讨冠心病患者中枢和外周TH敏感性指数与卒中的关系。提示冠心病患者中枢性TH敏感性指数的升高和外周TH敏感性指数的降低与卒中风险增加有关，为冠心病患者卒中的评估提供了新的思路。

REF: Pan G, Zhao G, Li L, et al. Association of thyroid hormone sensitivity index with stroke in patients with coronary artery disease. J Stroke Cerebrovasc Dis. 2024;33(2):107482. doi:10.1016/j.jstrokecerebrovasdis.2023.107482 PMID: 38061182

Is early initiated cardiorespiratory fitness training within a model of stroke-integrated cardiac rehabilitation safe and feasible?

在中风综合心脏康复模式下早期启动心肺适能训练是否安全可行？

To investigate the safety and feasibility of an early initiated stroke-integrated Cardiac Rehabilitation program. Cardiorespiratory fitness training in line with multiple clinical practice guidelines included within a model of stroke-integrated Cardiac Rehabilitation appears to be safe and feasible in the early subacute phase post-stroke.

探讨早期脑卒中合并心脏康复方案的安全性和可行性。在脑卒中后早期亚急性期，根据多个临床实践指南进行呼吸适能训练，包括在脑卒中综合心脏康复模型中是安全可行的。

REF: Machado N, Williams G, Olver J, Johnson L. Is early initiated cardiorespiratory fitness training within a model of stroke-integrated cardiac rehabilitation safe and feasible?. J Stroke Cerebrovasc Dis. 2024;33(2):107493. doi:10.1016/j.jstrokecerebrovasdis.2023.107493 PMID: 38061183

Proprotein convertase subtilisin/kexin type 9 inhibitor ameliorates cerebral ischemia in mice by inhibiting inflammation

枯草杆菌前蛋白转换酶/kexin 9抑制物通过抑制炎症改善小鼠脑缺血

To investigate the potential protective effects of evolocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, on ischemic stroke and its underlying mechanisms. Evolocumab protects against cerebral ischemic injury by inhibiting inflammation. Therefore, the TLR4/NF-кB pathway may represent a major mechanism in ischemic stroke.

探讨依洛普利（前蛋白转化酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂）对缺血性脑卒中的保护作用及其机制。依洛尤汀通过抑制炎症来保护脑缺血性损伤。因此，TLR4/NF—к B通路可能是缺血性脑卒中的主要机制。

REF: Chen L, Du Y, Qiao H, et al. Proprotein convertase subtilisin/kexin type 9 inhibitor ameliorates cerebral ischemia in mice by inhibiting inflammation. J Stroke Cerebrovasc Dis. 2024;33(2):107517. doi:10.1016/j.jstrokecerebrovasdis.2023.107517 PMID: 38056113

由人工翻译修正

Left atrial appendage occlusion in patients with spontaneous intracerebral hemorrhage: An observational study

自发性脑出血患者左心耳闭塞的观察研究

Patients with atrial fibrillation (AF) and intracerebral hemorrhage (ICH) are at high risk of ischemic and recurrent bleeding events. Therefore, the decision of restarting or avoiding anticoagulation is challenging. Left atrial appendage occlusion (LAAO) is an alternative for these patients. However, few data are available about safety of early LAAO and factors associated with ischemic stroke and ICH recurrence. In patients with ICH and AF, early LAAO was found to be safe and associated with a reduction in ischemic stroke. However, recurrent ICH risk remains high, and it appears to be mainly driven by cerebral amyloid angiopathy.

心房颤动(AF)和脑出血(ICH)患者发生缺血和复发出血事件的风险很高。因此，重新启动或避免抗凝的决定是具有挑战性的。左心耳闭塞(LAAO)是这些患者的另一种选择。然而，关于早期LAAO的安全性以及与缺血性卒中和脑出血复发相关的因素的数据很少。在ICH和房颤患者中，早期LAAO被发现是安全的，并与缺血性卒中的减少有关。然而，复发性脑出血的风险仍然很高，而且似乎主要是由脑淀粉样血管病变引起的。

REF: Moliner-Abós C, Albertí-Vall B, Millan-Álvarez X, et al. Left atrial appendage occlusion in patients with spontaneous intracerebral hemorrhage: An observational study. J Stroke Cerebrovasc Dis. 2024;33(2):107481. doi:10.1016/j.jstrokecerebrovasdis.2023.107481 PMID: 38064973

Feasibility and user-experience of a virtual environment for social connection and education after stroke: A pilot study

中风后社会联系和教育虚拟环境的可行性和用户体验：一项初步研究

To evaluate the feasibility and usability of stroke survivor participation in an 8-week virtual environment intervention that provides opportunities for social support exchanges, social network interactions, and recovery education. Overall, the results suggest that using a virtual environment to foster social support exchanges, social network interactions, and recovery education after stroke is feasible. Similar to other chronic disease populations, stroke survivor adoption of a virtual environment likely requires ongoing technical assistance, repetition of instructions, and opportunities for practice to reinforce engagement.

评估中风幸存者参与为期8周的虚拟环境干预的可行性和可用性，该干预提供了社会支持交流、社交网络互动和康复教育的机会。总体而言，研究结果表明，使用虚拟环境来促进社会支持交换、社交网络互动和中风后康复教育是可行的。与其他慢性病人群类似，中风幸存者采用虚拟环境可能需要持续的技术援助，重复指示，并有机会实践以加强参与。

REF: Beauchamp JES, Wang M, Leon Novelo LG, et al. Feasibility and user-experience of a virtual environment for social connection and education after stroke: A pilot study. J Stroke Cerebrovasc Dis. 2024;33(2):107515. doi:10.1016/j.jstrokecerebrovasdis.2023.107515 PMID: 38064972

Loss of Gucy1a3 causes poor post-stroke recovery by reducing angiogenesis via the HIF-1α/VEGFA signaling pathway in mice

Gucy1a3的缺失通过HIF—1 α/VEGFA信号通路减少血管生成而导致中风后恢复不良

Ischemic stroke is a common and debilitating disease that can cause permanent neurological damage. Gucy1a3, which encodes the α1 subunit of soluble guanylyl cyclase, has been reported to be associated with functional recovery after ischemic stroke. However, the mechanism is still not well understood. In the present study, we investigated the effects of Gucy1a3 on (i) post-stroke recovery; (ii) vascular endothelial growth factor A (VEGFA) and hypoxia inducible factor 1 alpha (HIF-1α) expression; and (iii) angiogenesis after ischemic stroke. Our study indicates that GUCY1A3 might be involved in angiogenesis after ischemic stroke. Further investigation of GUCY1A3 will provide a new therapeutic target for stroke.

缺血性中风是一种常见的、使人衰弱的疾病，可引起永久性的神经损伤。Gucy 1a3编码可溶性鸟苷酸环化酶α 1亚单位，已报道与缺血性脑卒中后功能恢复有关。然而，其机制仍不清楚。在本研究中，我们研究了Gucy1a3对（i）卒中后恢复；（ii）血管内皮生长因子A（VEGFA）和缺氧诱导因子1 α（HIF—1 α）表达；（iii）缺血性卒中后血管生成的影响。提示GUCY1A3可能参与缺血性脑卒中后血管生成。进一步研究GUCY1A3将为脑卒中的治疗提供新的靶点。

REF: Luo M, Mo D, Liu L, et al. Loss of Gucy1a3 causes poor post-stroke recovery by reducing angiogenesis via the HIF-1α/VEGFA signaling pathway in mice. J Stroke Cerebrovasc Dis. 2024;33(2):107484. doi:10.1016/j.jstrokecerebrovasdis.2023.107484 PMID: 38064974

The effect of age on the relationship between body mass index and risks of incident stroke subtypes: The JPHC study

年龄对体重指数与卒中发病亚型风险关系的影响：JPHC研究

The associations between body mass index (BMI) and stroke subtypes, particularly intracerebral hemorrhage, have not been consistent. Such inconsistencies may be due to differences in the age at which BMI was obtained. We examined the possible age modifications in the association between BMI and stroke risk. BMI and stroke associations did not vary significantly with age, although the association may differ according to subtype.

体重指数（BMI）与中风亚型，特别是脑出血之间的关系并不一致。这种不一致性可能是由于获得BMI的年龄差异所致。我们研究了BMI与中风风险之间可能的年龄变化。BMI和中风的相关性没有随年龄的变化显著，尽管这种相关性可能因亚型而异。

REF: Nuamah HG, Li Y, Yatsuya H, et al. The effect of age on the relationship between body mass index and risks of incident stroke subtypes: The JPHC study. J Stroke Cerebrovasc Dis. 2024;33(2):107486. doi:10.1016/j.jstrokecerebrovasdis.2023.107486 PMID: 38070372

Breakthrough of dual-phase CT angiography features of carotid web and its correlation with ischemic stroke

颈动脉网双期CT血管造影特征的突破及其与缺血性脑卒中的相关性

To investigate the diagnostic value of dual phase CT angiography (CTA) in carotid web and its correlation with ischemic stroke. Dual-phase CTA is effective and reliable method to identifying carotid webs, which may be associated with ischemic stroke.

探讨颈动脉网双期CT血管造影（CTA）的诊断价值及其与缺血性脑卒中的相关性。双期CTA是识别颈动脉网的有效、可靠的方法，可能与缺血性脑卒中有关。

REF: Li T, Zhang B, Zhang J. Breakthrough of dual-phase CT angiography features of carotid web and its correlation with ischemic stroke. J Stroke Cerebrovasc Dis. 2024;33(2):107530. doi:10.1016/j.jstrokecerebrovasdis.2023.107530 PMID: 38091848

Efficacy and safety of tirofiban combined with endovascular therapy for basilar artery occlusion stroke due to large artery atherosclerosis

替罗非班联合血管内治疗大动脉粥样硬化性基底动脉闭塞性脑卒中的疗效和安全性

This study aimed to evaluate the efficacy and safety of adjuvant tirofiban in patients with acute basilar artery occlusion due to large-artery atherosclerotic (LAA) receiving endovascular therapy (EVT). Tirofiban plus EVT might improve functional outcomes with a good safety for patients with acute basilar artery occlusion due to LAA. The results need to be confirmed in a randomized trial.

本研究旨在评价辅助替罗非班在接受血管内治疗（EVT）的大动脉粥样硬化（LAA）引起的急性基底动脉闭塞患者中的疗效和安全性。替罗非班联合EVT可改善因左心耳引起的急性基底动脉闭塞患者的功能结局并具有良好的安全性。结果需要在随机试验中得到证实。

REF: Zhu X, Guo Z, Tian L, et al. Efficacy and safety of tirofiban combined with endovascular therapy for basilar artery occlusion stroke due to large artery atherosclerosis. J Stroke Cerebrovasc Dis. 2024;33(2):107526. doi:10.1016/j.jstrokecerebrovasdis.2023.107526 PMID: 38096657